During the study, experts analyzed more than 11 thousand tissue samples from humans, mice, rats and macaques. This made it possible to identify common patterns of aging and identify molecular markers associated with the risk of developing chronic diseases and premature death.
The scientists paid special attention to the CDKN1A and LGALS3 genes. The study showed that the proteins associated with them can serve as indicators of accelerated aging and an increased likelihood of several chronic diseases at once.
According to the authors of the work, aging of the body is associated with a number of key processes, including chronic inflammation, accumulation of DNA damage, slowing of metabolism and a gradual decrease in cell functionality.
The developed algorithm makes it possible to analyze various biological processes inside cells and determine which body systems are aging faster than others. With its help, researchers have found that chronic diseases can accelerate aging through inflammatory mechanisms, while calorie restriction and certain genetic factors can positively affect the functioning of mitochondria and metabolism.
Experiments on animals and cell cultures have also shown that certain methods of exposure can slow down age-related changes and, in some cases, partially reverse them.
According to scientists, the results of the study open up new opportunities for the development of technologies and methods aimed at slowing down aging and maintaining health at the cellular level. The results of the work are published in the scientific journal Nature.
