Taiwanese researchers have developed an experimental vaccine based on induced pluripotent stem cells (iPSC), which has shown effectiveness in the prevention and treatment of colorectal cancer in mice. The work was published in the scientific journal Theranostics.
A team led by Professor Tsu-Tang Wei from the Medical College of National Taiwan University used iPSC lysates in combination with the immunostimulating agent CpG. This combination activated the immune response in the animals and significantly slowed the growth of tumors. Moreover, the vaccine also worked as a preventive measure.: mice that were injected with it before the tumor developed showed resistance to subsequent infection with cancer cells.
The method uses the potential of iPSC, which were previously used in regenerative medicine, but are now showing themselves to be a possible basis for universal cancer vaccines. Unlike traditional approaches to immunotherapy, this strategy covers a wider range of tumors and can potentially be used in different patients. lenta.ru.
